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Alzheimer's Disease - Dementia

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Alzheimer's Disease - Dementia

NIH - Medical Encyclopedia Alzheimer's Disease

"Alzheimer's disease (AD), one form of dementia, is a progressive, degenerative brain disease. It affects memory, thinking, and behavior. Memory impairment is a necessary feature for the diagnosis of this or any type of dementia. Change in one of the following areas must also be present: language, decision-making ability, judgment, attention, and other areas of mental function and personality. The rate of progression is different for each person. If AD develops rapidly, it is likely to continue to progress rapidly. If it has been slow to progress, it will likely continue on a slow course. There are two types of AD -- early onset and late onset. In early onset AD, symptoms first appear before age 60. Early onset AD is much less common, accounting for only 5-10% of cases. However, it tends to progress rapidly. The brain tissue shows "neurofibrillary tangles" (twisted fragments of protein within nerve cells that clog up the cell), "neuritic plaques" (abnormal clusters of dead and dying nerve cells, other brain cells, and protein), and "senile plaques" (areas where products of dying nerve cells have accumulated around protein). Although these changes occur to some extent in all brains with age, there are many more of them in the brains of people with AD."

Highlighted Articles

Education and Alzheimer disease without dementia: support for the cognitive reserve hypothesis. (Neurology. 2007)

"CONCLUSIONS: Regardless of the neuropathologic criteria used, education is predictive of dementia status among individuals with neuropathologic Alzheimer disease. These results support the theory that individuals with greater cognitive reserve, as reflected in years of education, are better able to cope with AD brain pathology without observable deficits in cognition."

Nutritional factors, cognitive decline, and dementia. (Brain Res Bull. 2006)

"Nutritional factors and nutritional deficiencies have been repeatedly associated with cognitive impairment. … Deficiencies of several B vitamins have been associated with cognitive dysfunction in many observational studies. More recently, deficiencies of folate (B(9)) and cobalamine (B(12)) have been studied in relation to hyperhomocysteinemia as potential determinants of cognitive impairment, dementia, and Alzheimer's disease (AD). A small number of studies assessed the association between intake of macronutrients and cognitive function or dementia. Among the others, the intake of fatty acids and cholesterol has received particular attention. Although the results are not always consistent, most studies have reported a protective role of dietary intakes of poly- and mono-unsaturated fatty acids against cognitive decline and AD."

Exercise Is Associated with Reduced Risk for Incident Dementia among Persons 65 Years of Age and Older (Annals of Internal Medicine 2006)

"Conclusion: These results suggest that regular exercise is associated with a delay in onset of dementia and Alzheimer disease, further supporting its value for elderly persons."

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Alzheimer's Disease - Dementia

General Information

NEWS:

Alzheimer’s Kills Many More Than Expected

Alzheimer's Strikes Women Harder Than Men: Report

Earlier age of dementia onset and shorter survival times in dementia patients with diabetes. (Am J Epidemiol. 2013)

Epilepsy Often Unrecognized in Early Alzheimer’s

Fight against Alzheimer's disease: New research on walnuts

If you think you have Alzheimer's, you just might be right, study suggests

Psychiatric Symptoms May Precede Cognitive Decline

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Shorter Stature Linked to Heightened Dementia Risk

Underactive Thyroid Not Linked to Memory Problems

Widowhood May Delay Dementia in Some Seniors, Study Finds

ARTICLES:

Dementia Pictures Slideshow: Disorders of the Brain

More Data on Diet and Dementia

JOURNAL ARTICLES:

Changes in tau phosphorylation levels in the hippocampus and frontal cortex following chronic stress. (Braz J Med Biol Res. 2014)

Charting the decline in spontaneous writing in Alzheimer's disease: a longitudinal study. (Acta Neuropsychiatr. 2014 )

Dementia is associated with iron-deficiency anemia in females: A population-based study. (J Neurol Sci. 2014 )

Early-onset Alzheimer's disease: a global cross-sectional analysis. (Eur J Neurol. 2014)

Effects of Dementia on Postoperative Outcomes of Older Adults With Hip Fractures: A Population-Based Study. (J Am Med Dir Assoc. 2014 )

Heart Diseases and Long-Term Risk of Dementia and Alzheimer's Disease: A Population-Based CAIDE Study. (J Alzheimers Dis. 2014 )

Low testosterone and the risk of dementia in elderly men: Impact of age and education. (Alzheimers Dement. 2013)

Serum 25-Hydroxyvitamin D and Cognitive Decline: A Longitudinal Study among Non-Demented Older Adults. (Dement Geriatr Cogn Disord. 2014)

Serum Lycopene, Lutein and Zeaxanthin, and the Risk of Alzheimer's Disease Mortality in Older Adults. (Dement Geriatr Cogn Disord. 2013)

Study: 1 in 3 Alzheimer's Cases 'Preventable'

Total Cholesterol and Neuropsychiatric Symptoms in Alzheimer's Disease: The Impact of Total Cholesterol Level and Gender. (Dement Geriatr Cogn Disord. 2014)

Vitamin D and the risk of dementia and Alzheimer disease. (Neurology. 2014 )

What is frontotemporal dementia? (Maturitas. 2014 )

Zinc and its effects on oxidative stress in Alzheimer's disease. (Neurol Sci. 2014)





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